The 5 Best Immunology Textbooks of 2021

Whether you’re a PhD or medical student taking an immunology course, a research scientist actively working within the field, or simply an avid learner, you are likely to find one of these textbooks useful for advancing your knowledge of immunology, a challenging subject that presents extensive terminology and a level of complexity that exceeds that of many other biology sub-disciplines. The five immunology textbooks that we have selected range from concise to comprehensive and should satisfy basic or clinical immunologists at all levels of training. Our team may earn a small commission from qualifying purchases made through the below links at no additional cost to you.

We believe that the five best immunology textbooks of 2021 are:

  • Janeway’s Immunobiology
  • Kuby Immunology
  • The Immune System by Peter Parham
  • Fundamental Immunology
  • Cellular and Molecular Immunology

Janeway’s Immunobiology, originally authored by the renowned late immunologist Charles Janeway, provides a detailed account of the field accompanied by engaging full-color illustrations. While neither the most comprehensive nor the most concise immunology textbook, Janeway’s book is thoughtfully designed and explores the field to a depth suitable for most readers. Clear explanations, integration of core principles with real-world applications, and a high level of readability make this textbook ideal for students taking an immunology course at the undergraduate, graduate, or medical school levels or professionals whose career involves immunology.

Whether you are taking an immunology course or simply looking to keep your understanding of the field up-to-date, this classic textbook will provide you with both depth and breadth of knowledge in modern basic and clinical immunology. The textbook is currently in its 9th Edition and has been updated to cover the latest developments in the field, particularly those related to the innate immune system. In addition, the online resources have been expanded to include a question bank and collectively add a lot of value.


Kuby Immunology is considerably shorter and less comprehensive than Janeway’s Immunobiology but still provides a satisfactory account of the field, covering the key concepts of an introductory immunology course with a high level of readability and clarity. Kuby’s text may be more useful for students taking undergraduate immunology courses or professionals looking to review essential points without going too in-depth. Similarly to Janeway’s Immunobiology, Kuby Immunology has numerous attractive illustrations and tables that enhance the reader’s experience.

Like Janeway’s Immunobiology, Kuby Immunology is a useful reference resource in addition to a learning aid. The book is fully referenced and highlights historically important literature articles with an experimental focus that some readers will appreciate. Kuby Immunology may be regarded as the textbook that best balances cost and detail, as all of the key concepts are covered in this more economical textbook.

Medical students studying immunology may find Kuby especially useful. Due to its focus on human immunology, some medical schools in the United States utilize the book as an accompaniment to lectures, and its clear figures and moderate level of detail are helpful for USMLE Step 1 exam preparation. However, keep in mind that at over 900 pages Kuby is not a quick read.

To this end, students seeking a more condensed book should consider Board Review Series Microbiology and Immunology, which was specifically developed with Step 1 in mind and includes both immunology concepts in an outline-like format and numerous USMLE-style review questions.

Individuals extremely strapped for time may need a textbook that condenses the content of Janeway’s even further. Written with simple language and only 160 pages, How the Immune System Works is ideal for anyone looking to rapidly learn big-picture immunology concepts. This is the book with “need to know” concepts for medical students with an upcoming immunology exam. In addition, some learners have found “How the Immune System Works” to be a useful gateway textbook for gaining exposure to the field prior to reading more in-depth texts.

Kuby Immunology, Board Review Series Microbiology and Immunology, and How the Immune System Works are arguably the best immunology textbooks for medical students.


The Immune System by Peter Parham is a shorter textbook, similar to Kuby Immunology, that serves as a useful resource for both students and professionals due to its clear writing style, attractive full-color illustrations, and relatively high level of detail. While both Kuby Immunology and The Immune System do not have the level of comprehensiveness that characterizes Janeway’s Immunobiology, they have a rich narrative and level of detail that are lacking in more concise review books such as Board Review Series Microbiology and Immunology. At just over 600 pages The Immune System is considerably shorter and more concise than Kuby Immunology. Dr. Parham’s book is a fascinating read but not the reference book that some readers would prefer.

The focus of this textbook on human immunology and its use of clinical examples may render it especially useful to medical, veterinary, pharmacy, dental, and pre-medical undergraduate students learning about the human immune system. End-of-chapter summaries are helpful for reviewing core concepts prior to exams.


Fundamental Immunology, edited by William Paul, is a comprehensive and thoughtfully-organized textbook suitable for professionals such as practicing physicians, basic and clinical research scientists, graduate students, and post-doctoral fellows. More akin to an encyclopedia than a novel, Fundamental Immunology is a heavy 1300-page textbook that is intended for advanced learners. Over one thousand pages of content make this textbook a useful reference resource for individuals whose careers involve the active application of immunology.

Keep in mind, however, that this is a basic science textbook and not a guide to patient care. You should also know that the latest edition of this textbook, the seventh edition, was published in 2012, and the field of immunology has developed considerably since then, though many fundamental concepts have not changed.

The seventh edition of the textbook includes numerous full-color illustrations and reference tables intended to provide efficient coverage of the field. Text and figures carry an extremely fine level of detail and are carefully referenced. Details on relevant scientific literature are provided at the end of each chapter for basic immunologists and other individuals interested in exploring immunology research on PubMed.

An even more detailed reference resource is the Encyclopedia of Immunobiology, edited by Michael Ratcliffe, which provides “the largest integrated source of immunological knowledge currently available.” Written by a team of experts and over 3000 pages in length, it is suitable for experimental and clinical immunologists in need of a highly detailed reference text. The latest edition of the textbook was published in 2016.


Cellular and Molecular Immunology by Abul Abbas, Andrew Lichtman, and Shiv Pillai is a comprehensive and well-written textbook with similar content to Janeway’s Immunobiology. The textbook maintains a clinical emphasis that would be helpful to learners with a greater interest in clinical immunology, such as translational research scientists and healthcare professionals involved in the investigation or treatment of human disease. The 9th edition of the textbook has been updated to include increased coverage of tumor immunity, innate immune signaling pathways, and immunodeficiencies.

Cellular and Molecular Immunology is the immunology textbook frequently used by MBBS (Bachelor of Medicine and Bachelor of Surgery) programs.

In addition to these textbooks, there are a number of others that may better suit your academic needs. It is important to recognize that the content of textbooks always lags behind that of the literature.

If you are looking to learn about the latest findings in a particular immunology sub-field, it may be better to consult a literature search engine such as PubMed.

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