Australian researchers found that T cells engineered to express the dendritic cell growth factor Flt3L overcame an important obstacle to the treatment of solid tumors.
Swiss scientists have found that the function of follicular dendritic cells within germinal centers is influenced by their spatial position.
Portuguese researchers discovered that type 1 regulatory T cells increase the availability of TGF-beta to promote CD8+ TRM T cell generation.
The team of Dr. Katerina Akassoglou at Gladstone Institutes and UCSF studied the gene signature of pathogenic innate immune cells in the CNS.
TUM researchers have found that methylglyoxal underlies MDSC-mediated immunosuppression with implications for cancer diagnosis and treatment.
Disulfiram, a drug approved by the FDA for treating alcohol addiction, has been found to antagonize inflammation and could treat key diseases .
Research by Dr. Arne Akbar and colleagues has shown that NK cell-like behavior of aging CD8+ T cells is linked to the expression of sestrins.
Researchers from TUM studying the T cell response to chronic infection have discovered a late dominance of low-affinity TCR clones.
Limited Efficacy of Immunosuppressive Strategy in Transplant Patients Associated with Immunoproteosome
The limited efficacy of a proteosome inhibitor-based immunosuppressive strategy in highly HLA-sensitized transplant recipients has been associated with the immunoproteosome.
Regulatory T cells control fibroblast activation in skin to suppress the pathogenesis of tissue fibrosis
The activity and function of regulatory T cells (Tregs) largely depends on the tissue in which they reside. Recent research has identified that Tregs in the skin are primed to control the pathogenesis of tissue fibrosis by expressing a unique transcriptional signature that supports the effective suppression of type 2 immune responses.