Dendritic Cell Activation Found to Boost Efficacy of T Cell Immunotherapies
Australian researchers found that T cells engineered to express the dendritic cell growth factor Flt3L overcame an important obstacle to the treatment of solid tumors.
Latest Research
Germinal Center Reaction Found to be Orchestrated by Distinct FDC Niches
Swiss scientists have found that the function of follicular dendritic cells within germinal centers is influenced by their spatial position.
Regulatory T Cells Found to Promote the Development of CD8+ TRM T Cells
Portuguese researchers discovered that type 1 regulatory T cells increase the availability of TGF-beta to promote CD8+ TRM T cell generation.
Researchers Profile Immune Cells Implicated in Neurodegenerative Diseases
The team of Dr. Katerina Akassoglou at Gladstone Institutes and UCSF studied the gene signature of pathogenic innate immune cells in the CNS.
MDSC Metabolite Found to Underly Immunosuppression, May Aid Cancer Therapy
TUM researchers have found that methylglyoxal underlies MDSC-mediated immunosuppression with implications for cancer diagnosis and treatment.
Addiction-Treating Drug Also Prevents Inflammation, Researchers Find
Disulfiram, a drug approved by the FDA for treating alcohol addiction, has been found to antagonize inflammation and could treat key diseases .
Altered Function of Aging CD8+ T Cells Linked to Stress-Sensing Sestrins
Research by Dr. Arne Akbar and colleagues has shown that NK cell-like behavior of aging CD8+ T cells is linked to the expression of sestrins.
T Cell Response to Chronic Infection Found to Favor Low-Affinity TCRs
Researchers from TUM studying the T cell response to chronic infection have discovered a late dominance of low-affinity TCR clones.
COVID-19: Considerations regarding the use of ACE inhibitors and ARBs
Concerns that use of ACE inhibitors and ARBs could increase susceptibility to COVID-19 are not fully supported by current research.
Coronavirus Source Potentially Traced to Malayan Pangolins
The coronavirus source may be traced to Malayan Pangolins, which could have served as intermediate hosts for a bat-derived virus.